Calamba City, Laguna: Two persons were killed while 16 other drug suspects were arrested following an anti-illegal drugs operation here on Wednesday morning. Supt. Albert Tapulao, City Chief of Police, identified the slain suspects as Nonie Matanguihan and Danilo Pisigan who resisted arrest and engaged policemen to a shoot out. Matanguihan died while being brought to a hospital while Pisigan died on the spot. Recovered from the suspects were two caliber 45 pistols and a hand grenade. Combined elements of Provincial Anti-Illegal Drugs Special Operations Task Force, Provincial Public Safety Company and Calamba City Police simultaneously served search warrants at several drug lairs in Barangay Parian, as part of the One Time Big Time Operation and arrested 16 suspects.