GAZA CITY, Palestinian Territories: Three senior Hamas commanders and four children were among at least 15 Palestinians killed in Gaza on Thursday as Israel stepped up air strikes on day 45 of the bloody conflict.

The leaders in the Ezzedine al-Qassam Brigades were among at least seven people killed when Israeli missiles totally destroyed a four-storey home in the southern city of Rafah before dawn, emergency services spokesman Ashraf al-Qudra said.

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