Human cloning with Chinese characteristics

0

BEIJING: China’s top geneticists say the country should set its own standards and regulations on human genome research, state-run media reported Wednesday, as ethical debate erupted over a Chinese study on modified human embryos.

Advertisements

Researchers from Guangzhou Medical University said they used a gene-editing technique known as CRISPR to artificially induce a mutation in human cells and make them resistant to HIV, the virus that causes AIDS.

Their paper, which appeared last week in the Journal of Assisted Reproduction and Genetics, is only the world’s second published account of gene editing in human embryos.

Critics said the study—intended as a proof-of-principle exercise—was unnecessary and lacked medical justification, and strongly cautioned against the broader ethical implications of the slippery slope of human genome modification.

“This paper doesn’t look like it offers much more than anecdotal evidence that (CRISPR) works in human embryos, which we already knew,” George Daley, a stem-cell biologist at Children’s Hospital Boston, told the prominent science journal Nature.

It demonstrated that “the science is going forward before there’s been the general consensus after deliberation that such an approach is medically warranted”, he added.

Tetsuya Ishii, a bioethicist at Japan’s Hokkaido University, denounced the research as “just playing with human embryos”, Nature said.

In a statement to China’s state-run Global Times newspaper, the paper’s lead author Fan Yong brushed aside such concerns.

“Regardless of criticism, which is not authoritative… we have to stick to the path, obtain independent intellectual property rights and a say” in international academia, he wrote.

“It is the pioneers that will make the rules in this field,” he added.

Han Bin, the director of China’s National Center for Gene Research, told the paper— which often takes a nationalistic tone—that the technology’s potential therapeutic benefits for all diseases caused by inherited variation, including cancer, should outweigh any qualms.

Instead of following other countries’ ethical stances, China should formulate its own standards and regulations, the Global Times cited him as saying.

Ethics committee

China is quickly cementing a reputation as a leader in the fields of genetic research and cloning, showing a willingness to forge ahead even as others hesitate over ethical issues.

The world’s biggest cloning factory is under construction in the northern port of Tianjin, with plans to churn out everything from pets to premium beef cattle.

The chief executive of Boyalife Group, the Chinese firm behind it, told Agence France-Presse his company had technology advanced enough to replicate humans. The head of its South Korean partner has been quoted as saying it preferred mainland locations to avoid bioethics laws elsewhere that would ban the use of human eggs.

The Guangzhou Medical University study used flawed embryos not viable for fertility treatment, and had been approved by the university’s ethics committee.

Four out of the 26 embryos were successfully modified, while a number exhibited unexpected mutations. All of them were destroyed three days later.

“The purpose of this study was to evaluate the technology and establish principles for the introduction of precise genetic modifications in early human embryos,” the Journal of Assisted Reproduction and Genetics paper read.

The first account of gene editing in human embryos was published last year by Chinese scientists from the same southern city. Their assertion that they had used CRISPR to modify a gene linked to a blood disease prompted outcry and calls for a moratorium on further research.

The legality of human embryo research varies by country, and there is no international consensus on what ought to be allowed.

In the US, the influential National Institutes of Health are banned from funding such studies, while Britain’s independent fertility regulator only issued its first licence for human embryo modification research in February, for a study on infertility and miscarriages. AFP

AFP/CC

 

Share.
loading...
Loading...

Please follow our commenting guidelines.

Comments are closed.