TEHRAN: Iranian researchers at Isfahan University of Technology, in association with their counterparts at the National University of Singapore, have developed nanofibrous gelatin skin for wound treatment.
Elham Vatankhah, a PhD student of Isfahan University of Technology in textile engineering and the project researcher, said the biodegradable nanofiber has been created from cellulose acetate/gelatin and it is an effective simulator of the structure and composition of native skin, Iran Daily wrote in its Monday edition.
ˈWe electrospun cellulose acetate/gelatin membranes in various compositions and evaluated their performance as a scaffold for skin tissue engineering and wound dressing,ˈ she said.
The expert noted that tissue-engineered scaffolds and wound dressings should be hydrophilic to allow oxygen and fluid exchange, and absorb excess exudates.
Vatankhah explained that a wound dressing should be easily removed without causing tissue damage and a tissue-engineered scaffold should be able to adhere to the wound and support cell proliferation during skin regeneration.
ˈWe changed the composition of cellulose acetate and gelatin in composite cellulose acetate/gelatin scaffolds and found that increasing the amount of gelatin will increase the adhesion properties of the nanofiber,ˈ she said.
Electrospun cellulose acetate/gelatin (25/75) nanofibers can be a potential tissue-engineered scaffold and the 75/25 can be a potential low-adherent wound dressing.
Electrospinning uses an electrical charge to draw very fine (typically on the micro or nano scale) fibers from a liquid.
Dermal fibroblasts are cells within the dermis layer of skin, which are responsible for generating connective tissue and allowing the skin to recover from injury. PNA