Lab-grown vocal cord tissue may offer transplant solution

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MIAMI: US researchers have grown vocal cord tissue in a lab, an advance that could one day help restore the voices of millions who suffer from cancer or other diseases, a study said Wednesday.

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For now, the research is in the early stages, according to the study in Science Translational Medicine.

The tissue has been shown to last for three months in mice that were engineered to have a human-like immune system, and produced sound vibrations when transplanted into intact voice boxes from dog cadavers.

Lead researcher Nathan Welham, a speech-language pathologist from the University of Wisconsin at Madison, said the advance is important because vocal cords are “an exquisite system and a hard thing to replicate.”

The bio-engineered tissue was grown over the course of two weeks, using healthy vocal fold cells — known as fibroblasts and epithelial cells — from surgical patients who had these cells removed for unrelated reasons, said the study.

The cells were isolated, purified and applied to a three-dimensional collagen scaffold, much like the kind scientists use to grow artificial skin in the lab.

When grown, the cells “assembled into layers that closely resembled the structure and protein makeup of natural vocal cord mucosa,” the study said.

To see if the engineered tissue would work, it was transplanted into voice boxes that had been excised from deceased dogs. When humid air was blown through, the tissue vibrated and produced sound the way scientists expected it would.

The engineered tissue also feels like natural vocal cords, and is moist and elastic like the real thing, Welham said.

While it will likely be years before such engineered tissue is widely available to those in need, researchers say their work is a promising step forward for the those with vocal cord dysfunction, which affects 20 million people in the United States and has no effective cure.

“Voice is a pretty amazing thing, yet we don’t give it much thought until something goes wrong,” said Welham.
AFP

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