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Sunday, September 07 2008

 

CENTER OF GRAVITY
By Rony V. Diaz
E. coli and you


PRO-LIFE advocates, if they were intellectually honest and consistent, should be standing up for all forms of life rather than just for human life.

On August 16, in this paper, a well-known pro-lifer said that a human fetus has “rights” that a porcine embryo does not have. This risible notion was made in support of a strident campaign against the Reproductive Health Bill.

There’s no basis, other than overweening arrogance, to the belief that human beings are unrelated to the other creatures on this planet, including to the billions of Escherichia coli that live in our guts.

The interconnectedness of life is the underlying theme of contemporary life sciences. As the French biologist, Jacques Monod, famously said, “What’s true for E.coli is true for the elephant.”

This is the subject of a fascinating book by Carl Zimmer, Microcosm: E. coli and the New Science of Life (Pantheon, New York, 2008).

Zimmer covers most of pre­sent-day biology, as he relates E.coli to almost every aspect of biotic life.

Among the things that we learn are how E.coli have sex, help each other during periods of stress, and defend themselves against “enemies.”

Until Joshua Lederberg and his collaborators discovered it, biologists did not believe that microbes could have sex. Lederberg showed a method of bacterial copulation by which E. coli exchanged genes.

Their social life is complex. When food is scarce, members of an E. coli community signal each other to enter a “stationary phase” in order to improve the changes of the entire colony to survive.

In the microbial world, as elsewhere, conflict is a fact of life. To defend themselves, E. coli produce chemical weapons that kill or repel their competitors.

Charles Darwin himself admitted that evolution “act[s] with extreme slowness.” If we were to go only by the fossil record, there are periods of “punctuated equilibrium,” to borrow Stephen Jay Gould’s terminology, in which nothing much seemed to have happened, but laboratory experiments with E. coli have shown adaptations in time scales short enough to be observed that confirm Darwin’s predictions.

When parents in Dover, Pennsylvania sued the local school board over the teaching of intelligent design as part of the science curriculum, E. coli played a key, if not a crucial, role.

The advocates of intelligent design said that the flagellum, a tail-like organ, was a structure too complex to have evolved by natural selection. Expert witnesses for the plaintiff demonstrated how it was possible for a flagellum to have evolved from intermediate structures even if it did not function for bacterial locomotion, thus discrediting one of the main arguments of proponents of intelligent design against the theory of evolution.

Biotechnology was a direct offshoot of research on E. coli. By inserting animal genes into E. coli, methods to produce insulin and other drugs in quantity were developed. By inserting E. coli genes into pigs, breaking down phosphate-bearing compounds in manure becomes possible, a solution to phosphate pollution that causes algal blooms that deplete oxygen in fresh water lakes and rivers.

As Zimmer explains, most of the discoveries that involved E. coli confirm the universality of biochemistry.

However, in studying the divergent behavior of genetically identical microbes, Zimmer was moved to warn “those who would put human nature down to any sort of simple genetic determinism.”

He hopes that the politically fraught debate on genetic engineering will produce “a deeper understanding of what it means to be human: not as an inviolable essence but as a complex cloud of genes, traits, environmental influences and cultural forces.”

Opposition to biotechnology and indeed to most of the recent discoveries in the life sciences remains alive and disruptive.

Will Zimmer’s warning and hope be heeded? Perhaps not. Biotechnology has become such an economic force that a reasoned and balanced response to it and to the biosciences has become difficult.

All that Zimmer could offer is an epigram: “Through E. coli we can see the history of life, and we can see its future as well.”

opinion@manilatimes.net  

   
 

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