OHIO: Three leading American drug distributors and an Israeli drugmaker blamed for a deadly US opioid epidemic settled a bellwether civil lawsuit with two Ohio counties Monday (Tuesday in Manila), opening the door for a broader national settlement worth $48 billion.

The $260-million deal with Ohio’s Summit and Cuyahoga counties set the basis for a resolution of lawsuits by some 2,700 addiction-ravaged communities nationwide that had joined the Cleveland case, the first in a federal court to address the causes of a crisis that has wrecked the lives of millions.

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