A malaria drug President Donald Trump took to try to prevent coronavirus disease 2019 (Covid-19) proved ineffective for that in the first large, high-quality study to test it in people in close contact with someone with the disease.

Results published Wednesday by the New England Journal of Medicine show that hydroxychloroquine was no better than placebo pills at preventing illness from the coronavirus. The drug did not seem to cause serious harm, though — about 40 percent on it had side effects, mostly mild stomach problems.

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